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    PLINEST (Polynucleotides)

    Polynucleotides are injectable treatments to improve skin texture (acne scars, fine lines, enlarged pores), under eye dark circles, and hair thinning.

    Plinest® is an injectable polynucleotide product aimed at improving skin texture, rejuvenation and hair loss.

    Polynucleotides are deoxyribonucleotide polymers (DNA fragments) extracted from fish, sterilised and ultra-purified to injectable products. Polynucleotides promote DNA synthesis, improve cell regeneration and cellular repair. They increase blood flow and nutrient supply to the cells. They also have additional benefits including anti-inflammatory and antioxidant properties. Collectively, these benefits lead to an overall improved skin quality. When the treatment is done on the scalp, it leads to an improved scalp skin quality and increased hair growth.

    They play a crucial role in improving skin quality and promoting bio-regeneration. This treatment is particularly helpful for those who want to target:

    • Acne scars
    • Skin dullness
    • Darkness and fine lines under eyes
    • Enlarged pores
    • Hair thinning / Hair loss

    Pre-treatment of the skin with polynucleotides before any procedure also helps to prepare the skin
    and makes it more receptive to medical, aesthetic, and anti-ageing treatments. It generates a synergistic effect in particular with laser, PRP, radiofrequency, fillers, peeling, micro-needling, and surgery.

    Frequently Asked Questions Gallery

      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • PLINEST for Female Pattern Hair Loss (Results from Mastelli - PLINEST)
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • PLINEST for Male Pattern Hair Loss (Courtesy of Dr Grasso)
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • DERMOSCOPIC improvement in hair density after PLINEST treatment for hair thinning (Results from Mastelli - PLINEST)
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • PLINEST for skin rejuvenation (Results from Mastelli - PLINEST)
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire
      • Dr Nicole Dermatology | Manchester | Warrington | Cheshire

    About Dr Nicole

    Find Out More About Your Experienced Consultant Dermatologist

    Frequently Asked Questions

    About Frequently Asked Questions
      • How safe is this procedure?

        Safety: No cases of severe side effects have been reported due to the highly bio-compatible nature of the gel/product.

      • How to patients respond to this procedure?

        In more than 90% of the subjects PN-HPTTM demonstrated overall clinical improvements of the skin texture and reductions of superficial fine wrinkles.

      • Areas of treatment?

        Scalp, face, neck and décolletage

      • Depth of injection?

        Superficially in the skin only.

      • How efficient is this procedure?

        Efficacy: 91% of patients demonstrated clinical improvement in the reduction of superficial fine lines and wrinkles based on physician assessment.
        +14.7% improvement in skin hydration vs baseline.
        +21.8% increase in skin elasticity.

      • What are the treatment protocols and injection techniques: for younger skin for bio-regeneration?

        A 2ml syringe is used at each session, and multiple micro-droplets are placed into the skin with intradermal injections. The recommended regime is 3 sessions about 2-4 weeks (on average 3 weeks) apart, and thereafter, 3 maintenance sessions per year.

      • What are the treatment protocols and injection techniques: acne scar improvement?

        Superficial injections are performed with micro-droplets placed into the acne scar areas to lift the scars. The treatment session is repeated every 2-4 weeks, for 2-3 sessions in total.

    1 Consultation

    PLINEST® are best suited for patients with acne scars, enlarged pores, fine lines under the eyes, and hair thinning. At your consultation, a full medical history will be taken. We will assess your concerns and determine if the use of PLINEST® is suitable for you. We will also go through the treatment procedure, treatment regimen, potential benefits and risks, as well as the likely treatment outcome.

    2 The Treatment

    Topical anaesthetic will be offered to reduce discomfort of the procedure. The skin will be cleansed with an antimicrobial solution. Multiple superficial injections are performed to deposit micro-droplets of polynucleotides into the skin. After the procedure, a soothing antiseptic cream will be applied.

    3 Aftercare

    You will be provided with an aftercare leaflet, aftercare advice and a post-procedure call by our team to ensure that all your concerns are addressed.

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